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ACG Releases New ALT Measurement Guidelines

Since 1999, Dr. Soloman Shah, MD, has practiced as a physician with Gastrointestinal Medical Associates in Reston, Virginia. Alongside his day-to-day clinical work, Dr. Soloman Shah, MD, maintains membership in the American College of Gastroenterology.

The American College of Gastroenterology (ACG) recently released new guidelines for physicians evaluating potential liver issues. According to the ACG, serum alanine aminotransferase (ALT) above 25 IU/L in females and above 33 IU/L in males should be considered abnormal and subject to further evaluation by doctors. This is the first time the ACG has updated these guidelines in more than a decade.

Stanford University School of Medicine’s Paul Y. Kwo, MD, FACG, says that information over the last ten years gathered from different patient groups around the world has led to the change in recommendations. He says that the increase in obesity among adults was also a major contributing factor. 

The ACG has developed an Abnormal Liver Chemistries Guideline that utilizes algorithms to help doctors properly assess the seriousness of different ALT levels. The guideline includes a graduated method of diagnosis ranging from minimal to severe and gives detailed direction on additional evaluation options when ALT levels fail to fall back to normal ranges.


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